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Invitrogen™ Cibisatamab Humanized Recombinant Human Monoclonal Antibody
Human Recombinant Monoclonal Antibody
Brand: Invitrogen™ MA542186
Denne vare kan ikke returneres.
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Beskrivelse
Endotoxin level < 0.01EU/μg by LAL method Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
Cibisatamab (CEA-TCB) is a T cell bispecific antibody that binds carcinoembryonic antigen (CEA) on cancer cells and CD3 on T cells. Cibisatamab has a single CD3epsilon chain binding site and two CEA binding sites on T cells (it regulates the binding affinity to cancer cells with high expression of CEA on the cell surface). This avoids targeting healthy epithelial cells with low CEA expression levels. T cell activation, cytokine secretion and release of cytotoxic particles are triggered by binding to CEA on the surface of cancer cells and CD3 on T cells.
Tekniske data
| Cibisatamab Humanized | |
| Recombinant Monoclonal | |
| Unconjugated | |
| CEA TCB; RG-7802; RO-6958688 | |
| Human CD3E/CEACAM5. | |
| 100 μg | |
| Primary | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid | |
| Chemical |
| ELISA, SDS-Page | |
| 2.54 mg/mL | |
| PBS with no preservative; pH 7.4 | |
| Human | |
| Protein A/G | |
| RUO | |
| Human | |
| Antibody | |
| IgG1 κ, IgG1 λ |
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Produkttitel
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