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Invitrogen™ Human CHEK2 (CHK2), His Tag Recombinant Protein

Artikelnummer. 10003492
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Mængde:
1 mg
Pakningsstørrelse:
1mg
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Artikelnummer. 10003492

Brand: Invitrogen™ PV3983

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Beskrivelse

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Full Length.

CHEK2 (CHK2) is a serine/threonine kinase and a component of the DNA damage checkpoint pathway. A mutation in CHK2 has been linked to cancer. CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control including tumor suppressor proteins. In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage. Chk2 is a putative tumor suppressor protein, with mutations in to the Chk2 gene linked to Li-Fraumeni syndrome, a familiar cancer usually associated with inherited mutations in TP53. Also, mutations in CHK2 are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.
TRUSTED_SUSTAINABILITY

Tekniske data

Adgangsnummer O96017
Koncentration See Label
Til brug med (applikation) Kinase Assay
Formulering 50mM tris with 50% glycerol, 0.04% Triton X-100, 150mM NaCl, 4mM DTT, 0.5mM EDTA and no preservative; pH 7.5
Gen-id (Entrez) 11200
Molekylvægt (g/mol) 66 kDa
Navn Human CHEK2 (CHK2), His Tag
pH-område 7.5
Oprensningsmetode Purified
Mængde 1 mg
Opbevaringskrav -80°C, Avoid Freeze/Thaw Cycles
Regulatorisk status RUO
Gene Alias CDS1; cds1 homolog; Checkpoint kinase 2; Checkpoint like protein CHK2; checkpoint-like protein CHK2; Chek2; Chk2; Chk2 (phospho T68); Chk2 (pThr68); CHK2 checkpoint homolog; CHK2 checkpoint homolog (S. pombe); Chk2 phospho; Chk2 phospho T68; del9; EC 2.7.11.1; hCds1; HuCds 1; HuCds1; kinase Chk2; LFS2; OTTHUMP00000199044; OTTHUMP00000199045; OTTHUMP00000199064; OTTHUMP00000199115; OTTHUMP00000199116; phospho Chk2 (T68); phospho Thr68 Chk2; PP1425; protein kinase Chk2; Rad53; Rad53 homolog; RP11-436C9.1; Serine/threonine protein kinase Chk2; serine/threonine-protein kinase Chk2
Fælles navn CHK2
Gen symbol Chek2
KinaseFamily RAD53 Kinase Family
Produkttype Protein
Konjugeret Unconjugated
Arter Human
Rekombinant Recombinant
Protein tag His-tag
Sekvens Full length
Indhold og opbevaring -80°C, Avoid Freeze/Thaw Cycles
Kinase Group Ser/Thr Kinases: CAMK Group
Forsendelsestilstand Dry Ice
Udtrykssystem Baculovirus
Protein form Full Length
Form Liquid
Forskningskategori Drug Development
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