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Invitrogen™ Human CHEK2 (CHK2), His Tag Recombinant Protein
Recombinant Protein
Brand: Invitrogen™ PV3983
This item is not returnable.
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Description
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Full Length
CHEK2 (CHK2) is a serine/threonine kinase and a component of the DNA damage checkpoint pathway. A mutation in CHK2 has been linked to cancer. CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control including tumor suppressor proteins. In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage. Chk2 is a putative tumor suppressor protein, with mutations in to the Chk2 gene linked to Li-Fraumeni syndrome, a familiar cancer usually associated with inherited mutations in TP53. Also, mutations in CHK2 are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.
Specifications
| O96017 | |
| Kinase Assay | |
| 11200 | |
| Human CHEK2 (CHK2), His Tag | |
| CDS1; cds1 homolog; Checkpoint kinase 2; Checkpoint like protein CHK2; checkpoint-like protein CHK2; Chek2; Chk2; Chk2 (phospho T68); Chk2 (pThr68); CHK2 checkpoint homolog; CHK2 checkpoint homolog (S. pombe); Chk2 phospho; Chk2 phospho T68; del9; EC 2.7.11.1; hCds1; HuCds 1; HuCds1; kinase Chk2; LFS2; OTTHUMP00000199044; OTTHUMP00000199045; OTTHUMP00000199064; OTTHUMP00000199115; OTTHUMP00000199116; phospho Chk2 (T68); phospho Thr68 Chk2; PP1425; protein kinase Chk2; Rad53; Rad53 homolog; RP11-436C9.1; Serine/threonine protein kinase Chk2; serine/threonine-protein kinase Chk2 | |
| RAD53 Kinase Family | |
| Human | |
| His-tag | |
| -80°C, Avoid Freeze/Thaw Cycles | |
| Dry Ice | |
| Full Length | |
| Drug Development |
| See Label | |
| 50 mM tris with 0.04% Triton X-100, 0.5 mM EDTA, 150 mM NaCl, 4 mM DTT, 50% glycerol and no preservative; pH 7.5 | |
| 66 kDa | |
| 1 mg | |
| CHK2 | |
| Unconjugated | |
| Recombinant | |
| Full length | |
| Ser/Thr Kinases: CAMK Group | |
| Baculovirus | |
| Liquid |
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