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STEMCELL Technologies CGP77675

Artikelnummer. 17140332
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Mængde:
5 mg
10 mg
Pakningsstørrelse:
5mg
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17140332 5 mg 5mg
17150332 10 mg -
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Artikelnummer. 17140332 Leverandør STEMCELL Technologies Leverandørnr. 74132

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Beskrivelse

Src family kinases inhibitor; Inhibits Src, LCK, Yes, Cdc2, EGFR, VEGFR, v-Abl, and FAK

  • CGP77675 is a potent inhibitor of Src family kinases
  • It has been reported to inhibit phosphorylation of peptide substrates and autophosphorylation of purified Src (IC50 = 5 - 20 nM and 40 nM, respectively), Src, and Src kinase family members such as LCK (IC50 = 0.02 mM and 0.29 mM, respectively)
  • It has also been shown to inhibit epidermal growth factor receptor (EGFR), Cdc2, v-Abl, and focal adhesion kinase (FAK) (IC50 = 0.15 mM, > 10 mM, 0.31 mM, and 0.2 mM, respectively; Missbach et al.)
  • In combination with the GSK3 inhibitor CHIR99021 (Catalog #72052), CGP77675 is used to maintain mouse embryonic stem (ES) cells (Shimizu et al.)
  • Preserves the epigenetic and genomic integrity as well as the developmental potential of ES cells (Choi et al.)

Tekniske data

CAS 234772-64-6
Mængde 5 mg
Molekylær formel C26H29N5O2
Renhed ≥98%
Produkttitel
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