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Ceritinib dihydrochloride, MedChemExpress

Artikelnummer. 16452807
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Artikelnummer. 16452807 Leverandør Medchem Express Leverandørnr. HY15656A

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Beskrivelse

MedChemExpress Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable and ATP-competitive ALK tyrosine kinase inhibitor with an IC50 of 200 pM. Ceritinib dihydrochloride (LDK378 dihydrochloride) also inhibits IGF-1R, InsR, and STK22D with IC50 values of 8, 7, and 23 nM, respectively. Ceritinib dihydrochloride (LDK378 dihydrochloride) shows great antitumor potency.

Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable and ATP-competitive ALK tyrosine kinase inhibitor with an IC50 of 200 pM. Ceritinib dihydrochloride (LDK378 dihydrochloride) also inhibits IGF-1R, InsR, and STK22D with IC50 values of 8, 7, and 23 nM, respectively. Ceritinib dihydrochloride (LDK378 dihydrochloride) shows great antitumor potency.

Tekniske data

Kemisk navn eller materiale Ceritinib dihydrochloride
CAS 1380575-43-8
Farve Light Yellow
Renhedsgrad noter Research
Molekylær formel C28H38Cl3N5O3S
Mængde 50 mg
Synonym LDK378 dihydrochloride
Opløselighedsinformation DMSO : 100 mg/mL (158.46 mM; Need ultrasonic) ∣H2O : 10 mg/mL (15.85 mM; Need ultrasonic)
SMIL CC(C)OC1=CC(C2CCNCC2)=C(C)C=C1NC3=NC=C(Cl)C(NC4=CC=CC=C4S(=O)(C(C)C)=O)=N3.[H]Cl.[H]Cl
Molekylvægt (g/mol) 631.06
Formel vægt 631.06
Procent renhed 99.0%
Grad Research
Fysisk form Solid
Til brug med (applikation) Cancer-Kinase/protease
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Research purposes only

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