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Tocris Bioscience™ Centrinone
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Artikelnummer. 18758578
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Mængde:
10 mg
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Artikelnummer. Mængde
18758578 10 mg
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Artikelnummer. 18758578 Leverandør Tocris Bioscience™ Leverandørnr. 5687/10

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Beskrivelse

High affinity and selective PLK4 inhibitor

High affinity and selective PLK4 inhibitor (Ki = 0.16 nM). Exhibits >1000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels in vitro. Induces cell cycle arrest in normal human cell lines in a p53-dependent manner. Decreases expression of pluripotency markers and induces differentiation in pluripotent stem cells.

Centrinone is a high affinity and selective PLK4 inhibitor (Ki = 0.16 nM). Exhibits >1000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels in vitro. Induces cell cycle arrest in normal human cell lines in a p53-dependent manner. Decreases expression of pluripotency markers and induces differentiation in pluripotent stem cells.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-morpholinyl)-4-pyrimidinamine
CAS 1798871-30-3
Mængde 10 mg
Mål Polo-like Kinase Inhibitors
Molekylær formel C26H25F2N7O6S2
Formel vægt 633.65
Renhed >98%
Produkttitel
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