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Invitrogen™ Human CDK9/Cyclin K, His Tag Recombinant Protein

Artikelnummer. 11593647
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Mængde:
10 μg
Pakningsstørrelse:
10µg
Artikelnummer. Mængde unitSize
11593647 10 μg 10µg
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Artikelnummer. 11593647

Brand: Invitrogen™ PV4335

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Beskrivelse

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Full Length

CDK9 is a serine/threonine kinase which when complexed with CyclinT1 forms an active holoenzyme complex. This complex plays a key role in regulating the eukaryotic cell cycle. CDK9 is coexpressed and copurified with CyclinT1. CDK9 regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors. CDK9 promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis. The CDK9/cyclin-K complex also has kinase activity towards CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy and confers a predisposition to heart failure.
TRUSTED_SUSTAINABILITY

Tekniske data

Adgangsnummer P50750
Koncentration See Label
Til brug med (applikation) Kinase Assay
Formulering 50 mM tris with 0.02% Triton X-100, 0.5 mM EDTA, 150 mM NaCl, 2 mM DTT, 50% glycerol and no preservative; pH 7.5
Gen-id (Entrez) 1025
Molekylvægt (g/mol) 91.8 kDa
Navn Human CDK9/Cyclin K, His Tag
Mængde 10 μg
Regulatorisk status For research use only. Not for use in diagnostic procedures
Gene Alias C-2 k; CDC2L4; CDC2-related kinase; Cdk9; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; CTK1; cyclin dependent kinase 9; cyclin-dependent kinase 9; cyclin-dependent kinase 9 (CDC2-related kinase); PITALRE; RP11-228B15.5; serine/threonine protein kinase PITALRE; Serine/threonine-protein kinase PITALRE; TAK; Tat-associated kinase complex catalytic subunit
Fælles navn CDK9
KinaseFamily CDK and CHK
Produkttype CDK9/Cyclin K Recombinant Human Protein
Konjugeret Unconjugated
Arter Human
Rekombinant Recombinant
Protein tag His-tag
Sekvens Full length
Indhold og opbevaring -80°C, Avoid Freeze/Thaw Cycles
Udtrykssystem Baculovirus
Protein familie Kinase and inhibitors
Form Liquid
Protein undertype Serine/threonine kinase
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