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CD8a Mouse anti-Human, Clone: C8/144B, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-0085-80

Additional Details : Weight : 0.01000kg

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Product Code. 15296777

  • 441.00 DKK / 25µg


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Description

Description

CD8 (Cluster of Differentiation 8) is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediate efficient cell-cell interactions within the immune system. The CD8 antigen acts as a co-receptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. CD8 is found on a T cell subset of normal cytotoxic/suppressor cells which make up approximately 20-35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer (NK) cells, subpopulations of peripheral blood null cells, thymocytes and bone marrow cells. The CD8 co-receptor functions as either a homodimer composed of two alpha chains, or as a disulfide-linked heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. The majority of CD8+ T cells express CD8 as a alpha/beta heterodimer. In HIV, the HIV-2 envelope glycoprotein binds CD8 alpha chain (but not the beta chain).
Specifications

Specifications

CD8a
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P01732
CD8, Leu-2, MAL, p32, CD8a
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Immunohistochemistry (Paraffin)
C8/144B
Unconjugated
CD8A
Liquid
CD8A
IgG1, kappa
25 μg
4° C
Primary
925
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