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Invitrogen™ CD59 Recombinant Rabbit Monoclonal Antibody (029), PerCP

Artikelnummer. 17810736
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Mængde:
100 Tests
Artikelnummer. Mængde
17810736 100 Tests
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Artikelnummer. 17810736

Brand: Invitrogen™ MA546754

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Beskrivelse

Rabbit Recombinant Monoclonal Antibody

Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Human CD59 (Met1-Glu101) and conjugated with PerCP under optimum conditions, the unreacted PerCP was removed. Storage: This antibody can be stored at 2C-8C for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). CD59 is the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 also associates with C5b-8 complex and counteracts appropriate formation of cytolytic pore within the plasma membrane. Further, CD59 is a low-affinity ligand of human CD2, causes T cell costimulation, and is involved in lymphocyte signal transduction. CD59 is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. Mutations in this gene cause CD59 deficiency, a disease involving hemolytic anemia, thrombosis, and cerebral infarction. Multiple alternatively spliced transcript variants of CD59 have been identified.
TRUSTED_SUSTAINABILITY

Tekniske data

Antigen CD59
Applikationer Flow Cytometry
Klassifikation Recombinant Monoclonal
Klon 029
Koncentration 100 μg/mL
Konjugeret PerCP
Formulering PBS with 0.5% BSA and 0.09% sodium azide
Gene CD59
Genadgangsnr. P13987
Gene Alias 16.3A5; 1F5; 1F5 antigen; 20 kDa homologous restriction factor; AA987121; Cb59b molecule; CD59; CD59 antigen; CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344); CD59 glycoprotein; CD59 molecule; CD59 molecule (CD59 blood group); CD59 molecule, complement regulatory protein; Cd59a; CD59a antigen; CD59A glycoprotein; Cd59b; CD59b antigen; CD59B glycoprotein; CD59b moleucle, complement regulatory protein; complement inhibitor CD59; complement regulatory protein; EJ16; EJ30; EL32; G344; HRF20; HRF-20; human leukocyte antigen MIC11; Ly-6-like protein; lymphocytic antigen CD59/MEM43; MACIF; MAC-inhibitory protein; MACIP; MAC-IP; MEM43; MEM43 antigen; membrane attack complex (MAC) inhibition factor; membrane attack complex inhibition factor; Membrane inhibitor of reactive lysis; MIC11; MIN1; MIN2; MIN3; MIRL; MSK21; p18-20; protectin; surface anitgen recognized by monoclonal antibody 16.3A5; T cell-activating protein
Gensymboler CD59
Værtsarter Rabbit
Immunogen Recombinant protein ecoding Human CD59 (Met1-Glu101).
Oprensningsmetode Protein A
Mængde 100 Tests
Regulatorisk status RUO
Primær eller sekundær Primary
Gen-id (Entrez) 966
Målarter Human
Indhold og opbevaring 4°C, store in dark, DO NOT FREEZE!
Produkttype Antibody
Form Liquid
Isotype IgG
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