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CD45.1 Mouse anti-Mouse, Clone: A20, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-0453-85

Additional Details : Weight : 0.01000kg

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Product Code. 15296967

  • 1574.00 DKK / 500µg


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Description

Description

CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells.
Specifications

Specifications

CD45.1
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P06800
CD45, L-CA, Lca, RT7, T200
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry, Immunoprecipitation
A20
Unconjugated
Ptprc
Liquid
Ptprc
IgG2a, kappa
500 μg
4° C
Primary
19264
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For Research Use Only.