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CD3 Mouse anti-Human, Super Bright 436, Clone: UCHT1, eBioscience™

Mouse Monoclonal Antibody

Brand:  Invitrogen 62-0038-42

Additional Details : Weight : 0.01000kg

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Product Code. 15855473

  • 2450.00 DKK / Pack of 100


Estimated Shipment date
from Supplier 05-06-2019
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Description

Description

Please refer to the datasheet for Super Bright Staining Buffer for more information. Excitation: 405 nm; Emission: 436 nm; Laser: Violet Laser The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.
Specifications

Specifications

CD3
Monoclonal
5 μL/Test
PBS with BSA and 0.09% sodium azide; pH 7.2
P07766
CD3E
IgG1, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
916
Flow Cytometry
UCHT1
Super Bright 436
CD3E
Liquid
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
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