missing translation for 'onlineSavingsMsg'
Learn More

CD267 (TACI) Rat anti-Mouse, APC, Clone: ebio8F10-3, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-5942-81

Additional Details : Weight : 0.25000kg

 View more versions of this product

Product Code. 15380790

  • 724.00 DKK / 50µg

In stock, ready to ship: 1

Please to purchase this item. Need a web account? Register with us today!


Description

Description

Description: The monoclonal antibody eBio8F10.3 recognizes TACI (Transmembrane Activator and Calcium-modulator and CAML Interactor) also known as CD267. TACI is a type III membrane protein belonging to the TNF receptor superfamily. The ligand for TACI has been shown to be BAFF (BLyS) and APRIL. TACI is expressed on the surface of a subset of maturing splenic B cells of the transitional type termed T2. Genetic studies have shown a role for TACI in both stimulation and inhibition of B cell proliferation. This actual role for TACI in the mouse has still not been determined. Recently human TACI has been shown to have repressive activities which inhibit BAFF-R function. Applications Reported: This ebio8F10-3 antibody has been reported for use in flow cytometric analysis. Applications Tested: This ebio8F10-3 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered.

Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 and April/TALL-2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non-immunological cell growth. Three receptors, BCMA, TACI, and BAFF-R, for BAFF and April were recently identified. TACI, like BCMA, binds BAFF and April. TACI and its ligands regulate humoral immune responses, activate NF-kappa-B and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.
Specifications

Specifications

CD267 (TACI)
Monoclonal
0.2 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
Q9ET35
CD267, CVID, CVID2, TACI, TNFRSF14B, transmembrane activator and CAML interactor, tumor necrosis factor receptor 13B, tumor necrosis factor receptor superfamily member 13B
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry
ebio8F10-3
APC
Tnfrsf13b
Liquid
Tnfrsf13b
IgG2a, kappa
50 μg
4° C, store in dark, DO NOT FREEZE!
Primary
57916
Videos
SDS
Documents

For Research Use Only.