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CD152 (CTLA-4) Monoclonal Antibody (14D3), eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

594.00 DKK - 1394.00 DKK

Specifications

Antigen CD152 (CTLA-4)
Clone 14D3
Concentration 0.5 mg/mL
Applications Flow Cytometry, Functional Assay, Neutralization
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15207257
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Affymetrix eBioscience
14-1529-82
100 μg
1394.00 DKK
100µg
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Estimated Shipment: 10-04-2024
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15297247
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Affymetrix eBioscience
14-1529-80
25 μg This item is currently unavailable or has been discontinued.
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Description

Description

Description: The 14D3 monoclonal antibody reacts with human CD152, also known as cytotoxic T lymphocyte antigen-4 (CTLA-4). CTLA-4, a protein with structural similarities to CD28, is expressed on activated T cells (activated B cells may also express CTLA-4) and binds the B7 family members, CD80 (B7-1) and CD86 (B7-2), with higher affinity than CD28 does. CTLA-4 and CD28 appear to deliver opposing signals to T cells: while CD28 is a potent costimulator, CTLA-4 restricts the progression of T cells to an activated state by inhibiting IL-2 secretion and cellular proliferation. The cytoplasmic portion of CTLA-4 contains ER retention motifs, resulting in intracellular localization of a large proportion of newly synthesized CTLA-4 in response to TCR signaling. The 14D3 antibody also recognizes rhesus monkey and has inhibitor activity. Applications Reported: The 14D3 antibody has been reported for use in flow cytometric analysis and immunoblotting (WB). 14D3 has also been reported in in vitro inhibition studies. (Please use Functional Grade purified 14D3, cat. 16-1529, in functional assays.). Applications Tested: The 14D3 antibody has been tested by intracellular staining and flow cytometric analysis of PHA stimulated normal human peripheral blood cells using the Intracellular Fixation & Permeabilization Buffer Set (cat. 88-8824) and protocol.

CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) is a CD28-family receptor expressed on mainly CD4+ T cells. It binds the same ligands as CD28 (CD80 and CD86 on B cells and dendritic cells), but with higher affinity than CD28. However, in contrast to CD28 which enhances cell function when bound at the same time as the T cell receptor, CTLA4 inhbits the T cell and prevents it from functioning. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function.
Specifications

Specifications

CD152 (CTLA-4)
0.5 mg/mL
Monoclonal
Liquid
RUO
P16410
CTLA4
Primary
4° C
CTLA4
14D3
Flow Cytometry, Functional Assay, Neutralization
Unconjugated
Mouse
Human, Rhesus Monkey
1493, 705673
IgG2a κ
Affinity chromatography
Antibody
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