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CD137 Ligand (4-1BB Ligand) Mouse anti-Human, PerCP-eFluor™ 710, Clone: 4H3, eBioscience™

Mouse Monoclonal Antibody

Brand:  Invitrogen 46-5906-42

Additional Details : Weight : 0.01000kg

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Product Code. 15855443

  • 2470.00 DKK / Pack of 100


Estimated Shipment date
from Supplier 04-06-2019
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Description

Description

Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically. Excitation: 488 nm; Emission: 710 nm; Laser: Blue Laser. Filtration: 0.2 μm post-manufacturing filtered. CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. CD137L is a co-stimulatory molecule that is expressed on antigen presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation. Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. Activated T cells also express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity. CD137L is also expressed on a majority of B-cell lymphomas, including mantle cell lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma (but it is lacking on Hodgkin lymphoma and T-cell lymphoma). CD137L is also expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interactions.
Specifications

Specifications

CD137 Ligand (4-1BB Ligand)
Monoclonal
5 μL/Test
0.2%PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
P41273
41BBL, TNFRSF9, 4-1BBL, TNFSF9, CDw137L
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
4H3
PerCP-eFluor™ 710
TNFSF9
Liquid
TNFSF9
IgG1, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
8744
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