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CBX4 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA512200
This item is not returnable.
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Description
This antibody is predicted to react with mouse based on sequence homology.
Polycomb group (PcG) proteins are chromatin-associated proteins which are important for embryonic and adult stem cell self-renewal and maintenance. At least two distinct human PcG complexes have been identified. Polycomb repressive complex I (PRC1) contains CBX4/Pc2, HPH1 and RING domain-containing proteins (RING1, RING2 and BMI1). CBX4 (Chromobox protein homolog 4 or PC2), which functions as a transcriptional suppressor, is a candidate of KyoT2-binding proteins. It is a E3 SUMO-protein ligase which facilitates SUMO1 conjugation. Depletion of CBX4 results in decreased cellular resistance to ionizing radiation. CBX4 is directly involved in the cellular response to DNA damage.
Specifications
| CBX4 | |
| Polyclonal | |
| PBS with 0.09% sodium azide | |
| O00257 | |
| CBX4 | |
| KLH conjugated synthetic peptide between 410-437 amino acids from the C-terminal region of human CBX4 | |
| 400 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
| Western Blot | |
| Unconjugated | |
| CBX4 | |
| Cbx4; chromobox 4; chromobox homolog 4; chromobox homolog 4 (Pc class homolog, Drosophila); chromobox protein homolog 4; chromobox-like protein 4; E3 SUMO-protein ligase CBX4; E3 SUMO-protein transferase CBX4; hPc2; MPc2; NBP16; NS5ATP1-binding protein 16; Pc class 2 homolog; PC2; Polycomb 2 homolog | |
| Rabbit | |
| Antigen affinity chromatography, Protein A | |
| RUO | |
| 8535 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |