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Tocris Bioscience™ Carfilzomib
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Artikelnummer. 18737066
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50 mg
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Artikelnummer. Mængde
18737066 50 mg
18726356 10 mg
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Artikelnummer. 18737066 Leverandør Tocris Bioscience™ Leverandørnr. 7188/50

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Beskrivelse

Potent irreversible proteasome inhibitor; active in vivo

Carfilzomib is a potent irreversible proteasome inhibitor. Preferentially inhibits the chymotrypsin-like β5 subunit of the constitutive 20S proteasome (IC50 = 5.2 nM) and the β5i subunit of the immunoproteasome 20Si (LMP7; IC50 = 14 nM) in vitro with minimal cross-reactivity to other proteases. Exhibits little or no effect on PGPH and T-L activities. Activates prosurvival autophagy and induces cell apoptosis. Acts synergistically with dexamethasone (Cat. No. 1126). Suppresses tumor growth in an in vivo xenograft model. Decreases bone resorption and enhances bone formation in non-tumor bearing mice.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale (αS)-α-[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1 S)-3-methyl-1-[[(2 R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide
CAS 868540-17-4
Mængde 50 mg
Mål Proteasome Inhibitors
Molekylær formel C40H57N5O7
Renhed 0.98
Produkttitel
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