missing translation for 'onlineSavingsMsg'
Få mere at vide
Få mere at vide
Invitrogen™ Cardiac Troponin I Monoclonal Antibody (16A11)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA120112
Denne vare kan ikke returneres.
Se returpolitik
Beskrivelse
MA1-20112 detects cardiac troponin 1 in human, mouse, rat, bovine, feline, canine, goat, porcine and rabbit samples.
Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that exists as part of a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin-t form, a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, anabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurements of blood TnI and TnT levels is an important diagnostics indicator of heart muscle damage, and can be used to differentiate between angina and myocardial infarction in patients with chest pains. Cardiac Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro. Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
Tekniske data
| Cardiac Troponin I | |
| Monoclonal | |
| 5.3 mg/mL | |
| PBS with 0.09% sodium azide; pH 7.4 | |
| P08057, P19429, P23693, P48787, Q863B6, Q8MKD5 | |
| TNNI3 | |
| Free human cardiac troponin I, native human cardiac troponin complex, or human cardiac troponin I peptides. | |
| 200 μg | |
| Primary | |
| Bovine, Canine, Feline, Goat, Human, Mouse, Pig, Rabbit, Rat | |
| Antibody | |
| IgG1 |
| Affinity Purification, ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot | |
| 16A11 | |
| Unconjugated | |
| TNNI3 | |
| alternatively spliced; cardiac ankyrin repeat kinase; Cardiac muscle troponin T; cardiac troponin I; cardiac troponin I isoform; cardiac troponin I-interacting kinase; cardiac troponin T; cardiac troponin T isoform 1; cardiac troponin T isoform 2; cardiac troponin T2; cardiomyopathy, dilated 1D (autosomal dominant); cardiomyopathy, dilated 2A (autosomal recessive); cardiomyopathy, hypertrophic 2; CARK; CCDD; CMD1D; CMD1FF; CMD2A; CMH2; CMH7; CMPD2; cTnI; cTnT; Ctt; CTTG; D830019J24Rik; LVNC6; MGC116817; RATCTTG; RCM1; RCM3; Serine/threonine-protein kinase TNNI3K; Tn1; TnI; TNNC1; Tnni3; TNNI3 interacting kinase; TNNI3-interacting kinase; TNNI3K; tnni3k {ECO:0000250; TNNT2; Tnnt3; TnTc; Tpn1; troponin 1, type 3; troponin I type 3 (cardiac); troponin I, cardiac 3; troponin I, cardiac muscle; troponin I, cardiac muscle-like; troponin I3, cardiac type; Troponin T cardiac; troponin T cardiac isoform; troponin T isoform 1; troponin T isoform 2; troponin T splicing mutant isoform 1; troponin T splicing mutant isoform 2; troponin T type 2 (cardiac); troponin T, cardiac muscle; troponin T2, cardiac; troponin T2, cardiac type; truncated cardiac troponin T; UniProtKB:Q59H18} | |
| Mouse | |
| Protein A | |
| RUO | |
| 100049696, 100860775, 21954, 29248, 403566, 493744, 511094, 7137 | |
| 4°C | |
| Liquid |
Korrektion af produktindhold
Dit input er vigtigt for os. Udfyld denne formular for at give feedback relateret til indholdet på dette produkt.
Produkttitel
Ser du en mulighed for forbedring?Del en indholdskorrektion