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Invitrogen™ Carbonic Anhydrase IX Polyclonal Antibody
Goat Polyclonal Antibody
Brand: Invitrogen™ PA547268
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Beskrivelse
In direct ELISAs, approximately 10% cross-reactivity with recombinant mouse CA9 is observed and less than 1% cross-reactivity with recombinant human CA1, 3, 4, 8, 10, 12, and 14 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.
Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. There are many genes that are inducible by hypoxia, via HIF-1 alpha. CA IX is one of the most inducible genes because of its stability and location within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. The pH is important in cell death under hypoxia, thus a blockade of CA IX results in increased cell death under hypoxia. Therefore, CA IX has become a reliable histochemical marker of hypoxia.
Tekniske data
| Carbonic Anhydrase IX | |
| Polyclonal | |
| Unconjugated | |
| CA9 | |
| Ca9; CA-9; CAIX; CA-IX; Car9; Carbonate dehydratase IX; carbonic anhydrase 9; Carbonic anhydrase IX; carbonic dehydratase; G250; Membrane antigen MN; membrane antigen MN homolog; MN; MN/CA9; P54 / 58N; P54/58N; pMW1; RCC-associated antigen G250; RCC-associated protein G250; renal cell carcinoma-associated antigen G250 | |
| Goat | |
| Antigen affinity chromatography | |
| RUO | |
| 768 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Lyophilized |
| Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry | |
| 0.2 mg/mL | |
| PBS with 5% trehalose and No Preservative | |
| Q16790 | |
| CA9 | |
| Mouse myeloma cell line NS0-derived recombinant human Carbonic Anhydrase IX Pro59-Asp414. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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