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Candesartan, 98%

Artikelnummer. 15405129
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100 mg
1 g
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100mg
1g
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Artikelnummer. 15405129 Leverandør Thermo Scientific Alfa Aesar Leverandørnr. J62818.MC
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Beskrivelse

Angiotensin II receptor antagonist | CAS: 139481-59-7 | C24H20N6O3 | 440.463 g/mol

Candesartan is a selective AT1 (angiotensin II receptor 1) antagonist. Antagonism of angiotensin receptors inhibits vasoconstriction and the production of aldosterone, leading to a decrease in water and sodium concentration in blood plasma. Exhibits antihypertensive effects in animal models. Used in treatment of congestive heart failure, as antihypertensive. Candesartan does not affect cell viability or proliferation but increases the expression of VEGF and interleukin-8 in the cultured medium of KU-19-19 cells. Candesartan (0.1 nM) could reduce the maximal contractile response to angiostensin II by approximately 50%.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in ethyl acetate, methanol, water (<1mg/mL at 25°C), DMSO (88 mg/ml at 25°C), and ethanol (1 mg/ml at 25°C).

Notes
Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.
TRUSTED_SUSTAINABILITY

Kemiske identifikatorer

CAS 139481-59-7
Molekylær formel C24H20N6O3
Molekylvægt (g/mol) 440.463
MDL nummer MFCD00081076
InChI nøgle HTQMVQVXFRQIKW-UHFFFAOYSA-N
Synonym candesartan, blopress, ratacand, 1-2'-1h-tetrazol-5-yl-1,1'-biphenyl-4-yl methyl-2-ethoxy-1h-benzo d imidazole-7-carboxylic acid, candesartan ban, 3h candesartan, unii-s8q36md2xx, 2-ethoxy-3-4-2-2h-tetrazol-5-yl phenyl phenyl methyl benzimidazole-4-carboxylic acid, candesartan usan/inn, candesartan usan:inn
PubChem CID 2541
ChEBI CHEBI:3347
IUPAC navn 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid
SMIL CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)O

Tekniske data

Kemisk navn eller materiale Candesartan
Smeltepunkt 183°C to 185°C
Farve White
Mængde 100 mg
Merck Index 14,1739
Opløselighedsinformation Soluble in ethyl acetate,methanol,water (<1mg/ml at 25°C),DMSO (88mg/ml at 25°C),and ethanol (1mg/ml at 25°C).
Formel vægt 440.45
Procent renhed 98%
Fysisk form Powder

Sikkerhed og håndtering

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Produktidentifikator
  • Candesartan
 Signalord
  • Advarsel
 Farekategori
  • Reproduktionstoksicitet Kategori 2
 Faresætning
  • H361d-Mistænkes for at skade det ufødte barn.
 Sikkerhedssætning
  • P201-Indhent særlige anvisninger før brug.
  • P280-Bær beskyttelseshandsker/beskyttelsestøj/øjenbeskyttelse/ ansigtsbeskyttelse.
  • P308+P313-VED eksponering eller mistanke om eksponering: Søg lægehjælp.
 Supplerende oplysninger
  • MIXTURE LIST-Contain: Candesartan

RUO – Research Use Only

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