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DiscoverX cAMP Hunter™ DLD1 ADRB3 Gs Cell Line
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Mængde:
2 hætteglas
Beskrivelse
The cAMP Hunter ADRB3 Gs cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. epinephrine and norepinephrine) based activation of ADRB3 GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wildtype ADRB3, a naturally Gs coupled GPCR. Upon activation of ADRB3, the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells.
Tekniske data
Tekniske data
| Assay Entry | Intracellular cAMP level |
| Cellelinje | DLD1 |
| Til brug med (applikation) | Cell Lines |
| Primær agonist | CGP12177A |
| Mængde | 2 hætteglas |
| Målindgang | ADRB3 |
| Adgangsnummer | NM_000025 |
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