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Tocris Bioscience™ Cambinol
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Artikelnummer. 18765386
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50 mg
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Artikelnummer. Mængde
18765386 10 mg
18748646 50 mg
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Artikelnummer. 18765386 Leverandør Tocris Bioscience™ Leverandørnr. 7137/10

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Beskrivelse

nSMase2 inhibitor

Cambinol is a neutral sphingomyelinase-2 (nSMase2) inhibitor (Ki = 7 μM; IC50 ∼ 7.7 μM). In vitro, Cambinol suppresses extracellular vesicle production and inhibits cell-to-cell tau propagation in tau biosensor cells. In vivo, Cambinol decreases tumor necrosis factor-α or interleukin-1β-induced increases of ceramide and cell death in primary neurons. Cambinol is neuroprotective and brain penetrant. Cambinol inhibits the activity of human SIRT1 and SIRT2 and exerts antitumor activity in vitro and in mouse xenograft studies.
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Tekniske data

Kemisk navn eller materiale 2,3-Dihydro-5-[(2-hydroxy-1-naphthalenyl)methyl]-6-phenyl-2-thioxo-4(1 H)-pyrimidinone
CAS 14513-15-6
Mængde 10 mg
Mål SMPD2
Molekylær formel C21H16N2O2S
Renhed 0.98
Produkttitel
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