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Tocris Bioscience™ C25-140
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Artikelnummer. 18768896
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10 mg
50 mg
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Artikelnummer. Mængde
18768896 50 mg
18766926 10 mg
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Artikelnummer. 18768896 Leverandør Tocris Bioscience™ Leverandørnr. 7715/50

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Beskrivelse

TRAF6-Ubc13 interaction inhibitor

C25-140 binds directly to TNF receptor-associated factor 6 (TRAF6) and inhibits its interaction with ubiquitin-conjugating enzyme Ubc13. C25-140 reduces TRAF6-Ubc13 activity and decreases NF-κB activation and inflammatory signaling in vitro. C25-140 exhibits selectivity for TRAF6 over other E3 ligases except cIAP1. In in vivo mouse models of autoimmune psoriasis and rheumatoid arthritis, the compound improves disease symptoms. The compound also suppresses the pro-inflammatory signaling activity of IL-17A and prevents its inhibitory effect on the anti-HBV action of IFN-α HepG2 cells.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 3-[3,5-Dimethyl-1-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazol-4-yl]-1-[4-(phenylmethyl)-1-piperidinyl]-1-propanone
CAS 1358099-18-9
Mængde 50 mg
Mål Ubiquitin Ligase (E3) Inhibitors
Molekylær formel C26H31N7O
Produkttitel
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