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Tocris Bioscience™ C 101248
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Artikelnummer. 18765715
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50 mg
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Artikelnummer. Mængde
18765715 50 mg
18786325 10 mg
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Artikelnummer. 18765715 Leverandør Tocris Bioscience™ Leverandørnr. 8007/50

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Beskrivelse

Selective and potent inhibitor of both mouse and human THIK-1

C 101248 is a selective and potent inhibitor of both mouse and human tandem pore domain halothane-inhibited K+ channel 1 (THIK-1, IC50 = 50 nM); it exhibits no activity against K2P family members, TREK-1 and TWIK-2, and Kv2.1. C 101248 blocks both tonic and ATP-evoked THIK-1 K+ currents in whole-cell patch-clamp recordings of mouse hippocampal microglia. C 101248 reduces neuroinflammation by preventing NLRP3-dependent release of IL-1β in isolated microglia.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 4-[1-(4-Pyridinylmethyl)-1 H-benzimidazol-2-yl]-1,2,5-oxadiazol-3-amine
CAS 361368-24-3
Mængde 50 mg
Mål Two-P Potassium Channels Blockers
Molekylær formel C15H12N6O
Renhed 0.98
Produkttitel
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