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STEMCELL Technologies BSI-201

Artikelnummer. 17130332
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50 mg
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17130332 50 mg
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Artikelnummer. 17130332 Leverandør STEMCELL Technologies Leverandørnr. 74122

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Beskrivelse

Cysteine-containing protein modifier; Inhibits growth of triple-negative breast cancer cells

  • BSI-201, also known as iniparib, can interact with the zinc finger domain of poly(ADP-ribose) polymerase 1 (PARP1) in vitro, but fails to inhibit the enzyme (Patel et al.) The nitroso metabolite of BSI-201 is highly reactive and forms non-specific covalent interactions with many cysteine-containing proteins (Liu et al.) BSI-201 has demonstrated anti-proliferative effects in triple-negative breast cancer cells (Chuang et al.; Yin et al.), and early studies indicated that it may be useful in treating early-stage triple-negative and BRCA1/2 mutation-associated breast cancer (O'Shaughnessy et al. 2009); however, its efficacy was later found to be insignificant (O'Shaughnessy et al.) 2014)

Tekniske data

CAS 160003-66-7
Synonym Iniparib; IND 71677
Mængde 50 mg
Molekylær formel C7H5IN2O3
Renhed ≥98%
Produkttitel
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