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STEMCELL Technologies Brefeldin A

Artikelnummer. 17130162
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10 mg
25 mg
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10mg
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Regulatorisk: Dette produkt falder ind under Lov om kemiske stoffer og produkter - lovbekendtgørelse nr. 1755 af 22. december 2006. Hvis det er relevant, skal kunden fremskaffe en licens før levering.
Artikelnummer. 17130162 Leverandør STEMCELL Technologies Leverandørnr. 73014

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Descrizione

Protein trafficking inhibitor; Inhibits Sec7-containing guanine-exchange factor (GEF)

  • Brefeldin A is a fungal lactone antibiotic, produced by many species, including Eupenicillium brefeldianum (Klausner et al.) It reversibly interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum by indirect inhibition of ADP-ribosylation factor (ARF; Klausner et al.; Helms & Rothman; Robinson et al.; Morinaga et al.; Moss & Vaughan; Nebenführ et al.; Ktistakis et al.) Brefeldin A binds to Sec7-containing guanine-exchange factor (GEF) at the ARF-GDP-Sec7 interface, preventing the conformational change required to release GDP and activate ARF (Mossessova et al.)

Specifica

CAS 20350-15-6
Synonym Ascotoxin; BFA; Cyanein; Decumbin; Nectrolide; NSC 56310; NSC 89671; NSC 107456; NSC 244390; Synergisidin
Mængde 25 mg
Molekylær formel C16H24O4
Renhed ≥98%
Titolo del prodotto
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