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Bortezomib, 98%

Artikelnummer. 15473159
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Denne vare kan ikke returneres. Se returpolicy
Regulatorisk: Dette produkt falder ind under Lov om kemiske stoffer og produkter - lovbekendtgørelse nr. 1755 af 22. december 2006. Hvis det er relevant, skal kunden fremskaffe en licens før levering.
Artikelnummer. 15473159 Leverandør Thermo Scientific Alfa Aesar Leverandørnr. J60378.MB
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Denne vare kan ikke returneres. Se returpolicy
Regulatorisk: Dette produkt falder ind under Lov om kemiske stoffer og produkter - lovbekendtgørelse nr. 1755 af 22. december 2006. Hvis det er relevant, skal kunden fremskaffe en licens før levering.

Beskrivelse

Bortezomib (CAS # 179324-69-7) is an inhibitor of protein degradation pathways. | CAS: 179324-69-7 | C19H25BN4O4 | 384.243 g/mol

A potent, highly selective and reversible inhibitor of the 20S proteasome, Bortezomib is used as an antineoplastic agent, which controls the growth of cancer cells. It is also useful in the treatment of multiple myeloma.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Bortezomib is an antineoplastic compound derived from boronic acid
• Bortezomib reversibly inhibits the 26S proteostome that maintains cell cycle pathways related to growth and division
• Bortezomib is an inhibitor of NF-κB, a factor that is constituitively active in some cancers

Application

• Bortezomib is suitable for use in the research of multiple myeloma and lymphomas, and for use in the research of protein degradation pathways
• Bortezomib is intended for in vitro and biochemical applications

TRUSTED_SUSTAINABILITY

Kemiske identifikatorer

CAS 179324-69-7
Molekylær formel C19H25BN4O4
Molekylvægt (g/mol) 384.243
MDL nummer MFCD09056737
InChI nøgle GXJABQQUPOEUTA-RDJZCZTQSA-N
Synonym bortezomib, velcade, bortezomib ps-341, dpba, pyz-phe-boroleu, unii-69g8bd63pp, velcade tn, bortezomib velcade, 1r-3-methyl-1-2s-1-oxo-3-phenyl-2-pyrazinylcarbonyl amino propyl amino butyl boronic acid, 1r-3-methyl-1-2s-3-phenyl-2-pyrazine-2-carbonylamino propanoyl amino butyl boronic acid
PubChem CID 387447
ChEBI CHEBI:52717
IUPAC navn [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid
SMIL B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O

Tekniske data

Kemisk navn eller materiale Bortezomib
Smeltepunkt 139°C to 143°C
Farve Brun til hvid
Mængde 25 mg
FN nummer UN3249
Merck Index 14,1351
Opløselighedsinformation Soluble in chloroform,dimethyl sulfoxide,ethanol and methanol.
Formel vægt 384.24
Procent renhed 99%
Fysisk form Pulver

RUO– Kun brug til forskning

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