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BIX-01294, MedChemExpress

Artikelnummer. 16484058
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Artikelnummer. Mængde
16484058 10 mg
16440417 50 mg
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Artikelnummer. 16484058 Leverandør Medchem Express Leverandørnr. HY10587

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Beskrivelse

MedChemExpress BIX-01294 is a reversible and highly selective G9a and GLP Histone Methyltransferase inhibitor, with IC50s of of 1.7 μM and 0.9 μM, respectively. BIX-01294 inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine residue. BIX-01294, a (1H-1,4-diazepin-1-yl)-quinazolin-4-yl amine derivative, induces necroptosis and autophagy. BIX-01294 has antitumor activity in recurrent tumor cells.

BIX-01294 is a reversible and highly selective G9a and GLP Histone Methyltransferase inhibitor, with IC50s of of 1.7 μM and 0.9 μM, respectively. BIX-01294 inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine residue. BIX-01294, a (1H-1,4-diazepin-1-yl)-quinazolin-4-yl amine derivative, induces necroptosis and autophagy. BIX-01294 has antitumor activity in recurrent tumor cells.

Tekniske data

Kemisk navn eller materiale BIX-01294
CAS 935693-62-2
Farve Off-White
Renhedsgrad noter Research
Molekylær formel C28H38N6O2
Mængde 10 mg
Opløselighedsinformation DMSO : ≥ 110 mg/mL (224.20 mM) ∣H2O : 1 mg/mL (2.04 mM; Need ultrasonic)
SMIL COC1=C(OC)C=C(C(NC2CCN(CC3=CC=CC=C3)CC2)=NC(N4CCN(C)CCC4)=N5)C5=C1
Molekylvægt (g/mol) 490.64
Formel vægt 490.64
Procent renhed 98.0%
Grad Research
Fysisk form Solid
Til brug med (applikation) Cancer-programmed cell death
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Research purposes only

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