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STEMCELL Technologies BIO-Acetoxime

Artikelnummer. 17170202
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Mængde:
1 mg
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Artikelnummer. Mængde
17170202 1 mg
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Artikelnummer. 17170202 Leverandør STEMCELL Technologies Leverandørnr. 73322

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Beskrivelse

WNT pathway activator; Inhibits GSK3

  • BIO-Acetoxime is an analog of the GSK3 inhibitor BIO (Catalog #72032)
  • It potently inhibits GSK3α and GSK3β (IC50 = 10 nM), and less potently inhibits cyclin-dependent kinases Cdk5/p25, Cdk2/A, and Cdk1/B (IC50 = 2.4, 4.3, and 63 μM, respectively; Meijer et al.; Polychronopoulos et al.) By inhibiting GSK3β, BIO-Acetoxime blocks β-catenin phosphorylation and degradation, thereby allowing it to activate transcription of WNT pathway-controlled genes (Meijer et al.)
  • Inhibits CD8+ effector T cell differentiation (Zhou et al.)
  • Suppresses viral gene expression and protects oral epithelial cells from herpes simplex virus-1 infection (Hsu & Hung)

Tekniske data

CAS 740841-15-0
Synonym 6-Bromoindirubin-3’-acetoxime; BIA; GSK-3 inhibitor X
Mængde 1 mg
Molekylær formel C18H12BrN3O3
Renhed ≥95%
Produkttitel
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