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Tocris Bioscience™ beta-GalNAc-PEG4-Azide

Artikelnummer. 18715676
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Mængde:
25 mg
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18715676 25 mg
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Artikelnummer. 18715676 Leverandør Tocris Bioscience™ Leverandørnr. FAB10988S100UG

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Beskrivelse

Asialoglycoprotein receptor ligand with PEG4 linker and azide group for onward chemistry

β-GalNAc-PEG4-Azide is a functionalized asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development; incorporates a single ASGPR ligand with a PEG4 linker and azide group reactive handle ready for conjugation. It can be used as a building block for multivalent compounds to enhance ASGPR binding. Upon binding to ASGPR, β-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. β-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes. Can be used to generate LYTACs, or labeled with dye for tissue imaging.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl 2-(acetylamino)-2-deoxy-β-D-galactopyranoside
CAS 879004-92-9
Mængde 25 mg
Mål ASGPR1
Molekylær formel C16H30N4O9
Produkttitel
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