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Invitrogen™ beta Arrestin 1 Polyclonal Antibody

Artikelnummer. 16566021
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100 μL
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16566021 100 μL
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Artikelnummer. 16566021 Leverandør Invitrogen™ Leverandørnr. PA587555

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Beskrivelse

Rabbit Polyclonal Antibody

Immunogen sequence: RKVQYAPERP GPQPTAETTR QFLMSDKPLH LEASLDKEIY YHGEPISVNV HVTNNTNKTV KKIKISVRQY ADICLFNTAQ YKCPVAMEEA DDTVAPSSTF CKVYTLTPFL ANNREKRGLA LDGKLKHEDT NLASSTLLRE GANREILGII VSYKVKVKLV VSRGGLLGDL ASSDVAVELP FTLMHPKPKE EPPHREVPEN ETPVDTNLIE LDTNDDDIVF EDFARQRLKG MKDDKEEEED GTGSPQLNNR; Positive Samples: U-937, K-562, Mouse brain, Mouse spleen; Cellular Location: Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Membrane, Nucleus, clathrin-coated pit, pseudopodium.

Beta Arrestin 1 is a member of a family of proteins widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling and mediates agonist-dependent desensitization and internalization of Gprotein-coupled receptors (GPCRs, e.g., beta 2-adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G-protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.
TRUSTED_SUSTAINABILITY

Tekniske data

Antigen beta Arrestin 1
Applikationer ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Klassifikation Polyclonal
Koncentration 1.85 mg/mL
Konjugeret Unconjugated
Formulering PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene ARRB1
Genadgangsnr. P29066, P49407, Q8BWG8
Gene Alias 1200006I17Rik; ARB1; ARR1; ARRB1; ARRB1 protein; arrdc1; arrestin; arrestin 2; arrestin beta 1; arrestin beta-1; arrestin, beta 1; arrestin-2; AW208571; BARRES; beta-arrestin; beta-arrestin1; beta-arrestin-1; G430100A01Rik; Non-visual arrestin-2
Gensymboler ARRB1
Værtsarter Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 169-418 of human beta-arrestin1 (NP_0040322).
Oprensningsmetode Affinity chromatography
Mængde 100 μL
Regulatorisk status RUO
Primær eller sekundær Primary
Gen-id (Entrez) 109689, 25387, 408
Målarter Human, Mouse, Rat
Indhold og opbevaring -20°C, Avoid Freeze/Thaw Cycles
Produkttype Antibody
Form Liquid
Isotype IgG
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