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Berberine chloride

Artikelnummer. 15424719
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Mængde:
5 g
Pakningsstørrelse:
5g
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Artikelnummer. 15424719 Leverandør Thermo Scientific Alfa Aesar Leverandørnr. J62311.06
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Beskrivelse

CAS: 633-65-8 | C20H18ClNO4 | 371.817 g/mol

Berberine is an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme Cox-2 (cyclooxygenase-2) which is abundantly expressed in colon cancer cells. Also inhibits c-Jun (Activator Protein 1), a transcription factor that plays a critical role in inflammation and carcinogenesis. Berberine upregulates the expression of Pgp in hepatoma cells. Treatment with berberine potentially results in the reduced accumulation of chemotherapeutic drugs.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in dimethyl sulfoxide (74 mg/ml at 25°C), ethanol (<1mg/mL at 25°C), water (<1mg/mL at 25°C), and methanol.

Notes
Store at -20°C. Incompatible with oxidizing agents. Protect from heat.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale Berberine chloride
CAS 633-65-8
Farve Yellow to Orange
Molekylær formel C20H18ClNO4
MDL nummer MFCD00011939
Mængde 5 g
Beilstein 3836585
Synonym berberine chloride, berberine hydrochloride, natural yellow 18, benzodioxide, berberinium chloride, berberine hcl, unii-uot4o1byv8, berberine chloride jan, uot4o1byv8
Opløselighedsinformation Soluble in dimethyl sulfoxide (74mg/ml at 25°C),ethanol (<1mg/ml at 25°C),water (<1mg/ml at 25°C),and methanol.
InChI nøgle VKJGBAJNNALVAV-UHFFFAOYSA-M
SMIL COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-]
Molekylvægt (g/mol) 371.817
PubChem CID 12456
ChEBI CHEBI:31271
Formel vægt 371.82
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