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Belnacasan, MedChemExpress

Artikelnummer. 16496106
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16496106 100 mg
16485548 10 mg
16471717 50 mg
16458257 5 mg
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Artikelnummer. 16496106 Leverandør Medchem Express Leverandørnr. HY13205

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Beskrivelse

MedChemExpress Belnacasan (VX-765) is an orally bioactive prodrug of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with Kis of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ∼0.7 μM.

Belnacasan (VX-765) is an orally bioactive prodrug of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with Kis of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ∼0.7 μM.

Specifica

Kemisk navn eller materiale Belnacasan
Fysisk form Powder
CAS 273404-37-8
Farve White
Mængde 100 mg
Renhedsgrad noter Research
Molekylær formel C24H33ClN4O6
Til brug med (applikation) COVID-19-immunoregulation
Synonym VX-765
Opløselighedsinformation DMSO : 260 mg/mL (510.81 mM; Need ultrasonic) ∣H2O : 1 mg/mL (1.96 mM; ultrasonic and warming and heat to 60°C)
SMIL ClC1=C(N)C=CC(C(N[C@@H](C(C)(C)C)C(N2[C@H](C(N[C@H]3CC(O[C@H]3OCC)=O)=O)CCC2)=O)=O)=C1
Molekylvægt (g/mol) 509.0
Formel vægt 509.0
Procent renhed 98.03%
Grad Research
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Research purposes only

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