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BD Caspase-8

Artikelnummer. 15808718 Shop alle BD Biosciences produkter
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Koncentration:
0,2 mg/ml
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Artikelnummer. Koncentration
15808718 0,2 mg/ml
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Artikelnummer. 15808718 Leverandør BD Leverandørnr. 556481

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Beskrivelse

Play role in apoptosis induced by death receptors

Caspases are cysteine proteases that play central role in apoptosis. The caspase family was discovered by searching human cDNA libraries for sequences homologous to ced-3, a C. elegans death gene that is required for normal apoptosis during development

  • Fas and tumor necrosis factor receptor type 1 (TNFR1)
  • One of its substrates is poly (ADP ribose) polymerase (PARP)
  • PARP is an enzyme that is involved in DNA repair and genomic maintenance
  • Cleaves PARP from its 116kDa form to 85kDa residual fragment
  • The cleavage site in PARP is C-terminal to Asp-216
  • Utilized as basis for highly specific caspase-3 substrates such as Ac(N-acetyl)-DEVD-AFC (7-amino-4-trifluoromethylcourmarin) and Ac(N-acetyl)-DEVD-AMC (7-amino-4-methylcoumarin) as well as caspase-3 aldehyde inhibitor Ac-DEVD-CHO
  • Format: Purified

Fluorescence quantitation

TRUSTED_SUSTAINABILITY

Tekniske data

Koncentration 0,2 mg/ml
Til brug med (applikation) Fluorescence Quantitation
Navn Human Caspase-8 Protease Recombinant Protein
Mængde 5μg
Opbevaringskrav -80°C
Krydsreaktivitet Human
Rekombinant Recombinant

Research use only

Produkttitel
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