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BD Caspase-3 Enzyme Set

Artikelnummer. 15898708
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15898708 ADN
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Artikelnummer. 15898708 Leverandør BD Leverandørnr. 556473

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Beskrivelse

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Recombinant Human Active Caspase-3: 5μg, Ac-DEVD-AFC, Caspase-3 Fluorogenic Substrate: 1.0mg, Ac-DEVD-CHO, Caspase-3 Inhibitor: 1.0mg

Gene that is required for normal apoptosis during development

Caspases are cysteine proteases that play central role in apoptosis. The caspase family was discovered by searching human cDNA libraries for sequences homologous to ced-3, a C. The rate of caspase-3 enzymatic hydrolysis can be measured by release of AFC, from Ac-DEVD-AFC caspase substrate, through emission at 480-520nm (peak at 505nm) upon excitation at 400nm using UV spectrofluorometry

  • Consisting of 12kDa and 17kDa subunit derived from 32kDa pro-enzyme (pro- caspase-3)
  • Cleaves PARP, an enzyme that is involved in DNA repair and genomic maintenance
  • The cleavage site in PARP is C-terminal to Asp-216
  • Cleaves the tetrapeptide between D and AFC, thus releasing the fluorogenic AFC
  • Expressed in E.coli and purified

Enzyme assay

TRUSTED_SUSTAINABILITY

Tekniske data

Til brug med (applikation) Enzyme Assay
Navn Caspase-3 Enzyme Set
Mængde 20 Tests
Opbevaringskrav -80°C
Krydsreaktivitet ADN

Research use only

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