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Tocris Bioscience™ BAY 876

Artikelnummer. 18749246
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Mængde:
5 mg
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18749246 5 mg
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Artikelnummer. 18749246 Leverandør Tocris Bioscience™ Leverandørnr. 6199/5

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Beskrivelse

Potent and selective GLUT1 inhibitor

BAY 876 is a potent and selective GLUT1 inhibitor (IC50 = 2 nM) that displays selectivity for GLUT1 over GLUT2/3/4 (IC50 values are 10.8, 1.67 and 0.29 μM, respectively). BAY 876 induces cell death in hypoxic conditions in vitro and inhibits glucose uptake by Hela-MaTu cells. In ovarian cancer, BAY 876 reduces glycolysis rates and ATP production and inhibits proliferation in vitro and in vivo. This compound is cell permeable and orally bioavailable.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale N4-[1-[(4-Cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-quinolinedicarboxamide
CAS 1799753-84-6
Mængde 5 mg
Molekylær formel C24H16F4N6O2
Renhed 98%
Produkttitel
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