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  5. Tocris™ BAY 87-2243

Tocris™ BAY 87-2243

Artikelnummer. 18778836
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Mængde:
5 mg
25 mg
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Artikelnummer. Mængde
18778836 5 mg
18788036 25 mg
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Artikelnummer. 18778836 Leverandør Tocris™ Leverandørnr. 6980/5

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Beskrivelse

Mitochondrial complex I inhibitor

BAY 87-2243 is a mitochondrial complex I inhibitor. Exhibits no effect on mitochondrial complex III. Induces mitochondrial permeability transition pore (mPTP) opening, stimulates autophagosome formation and mitophagy, and increases ROS levels. Activates necroptotic and ferroptotic cell death. Also inhibits hypoxia-induced gene activation. Induces cell death in melanoma cell lines in vitro and exhibits antitumor activity in a mouse NSCLC xenograft model in vivo.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 1-Cyclopropyl-4-[4-[[5-methyl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]-1H-pyrazol-1-yl]methyl]-2-pyridinyl]piperazine
CAS 1227158-85-1
Mængde 5 mg
Molekylær formel C26H26F3N7O2
Renhed 98%
Produkttitel
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