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Description
Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H+-ATPase (V-ATPase) with IC50 values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes of cultured cells. Bafilomycin A1 induces apoptosis.
Specifications
Specifications
Chemical Name or Material | Bafilomycin A1 |
Physical Form | Powder |
CAS | 88899-55-2 |
Color | White |
Quantity | 100 μg |
Purity Grade Notes | Research |
Molecular Formula | C35H58O9 |
For Use With (Application) | Cancer-programmed cell death |
Synonym | BafA1 |
Solubility Information | DMSO : 100 mg/mL (160.56 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble) |
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Research purposes only
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Product Title
Bafilomycin A1, MedChemExpress
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