missing translation for 'onlineSavingsMsg'
Få mere at vide
  1. Home
  2. Products
  3. Proteinanalysereagenser
  4. Bioaktive små molekyler
  5. STEMCELL Technologies AZD6244

STEMCELL Technologies AZD6244

Artikelnummer. 17180152
Encompass_Preferred
Skift visning
Klik for at se tilgængelige muligheder
Mængde:
10 mg
50 mg
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Artikelnummer. Mængde
17180152 10 mg
17190152 50 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
Denne vare kan ikke returneres. Se returpolicy
Artikelnummer. 17180152 Leverandør STEMCELL Technologies Leverandørnr. 72992

Please to purchase this item. Need a web account? Register with us today!

Denne vare kan ikke returneres. Se returpolicy

Beskrivelse

MEK/ERK pathway inhibitor; Inhibits MEK1 and MEK2

  • AZD6244 is a potent, highly selective inhibitor of the mitogen-activated protein kinases MEK1 (IC50 = 14 nM) and MEK2 (Kd = 530 nM; Yeh et al.; Davis et al.) It is a tight-binding noncompetitive inhibitor that does not bind in the ATP binding pocket of MEK (Huynh et al.) It also shows micromolar binding to epidermal growth factor receptor (EGFR; Davis et al.)
  • Inhibits growth of several tumor cell lines but not normal fibroblast lines, and inhibits tumor growth in a colorectal xenograft tumor model (Yeh et al.)
  • Inhibits proliferation and induces differentiation and apoptosis in multiple tumor cell lines and tumor xenograft models, especially those containing BRAF or RAS mutations (Davies et al.)
  • Inhibits proliferation of breast cancer and non-small cell lung cancer cell lines, especially those containing RAF and RAS mutations, respectively (Garon et al.)

Tekniske data

CAS 606143-52-6
Synonym ARRY-142886; Cl-1040; G 00039805; NSC 741O78; Selumetinib
Mængde 10 mg
Molekylær formel C17H15BrClFN4O3
Renhed ≥95%
Produkttitel
Vælg et problem

Ved at klikke på Send, anerkender du, at du kan blive kontaktet af Fisher Scientific med hensyn til den feedback, du har givet i denne formular. Vi deler ikke dine oplysninger til andre formål. Alle angivne kontaktoplysninger skal også vedligeholdes i overensstemmelse med vores Privatlivspolitik.