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Tocris Bioscience™ AZD 7648
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Product Code. 18779796
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50 mg
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18779796 10 mg
18799076 50 mg
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Product Code. 18779796 Supplier Tocris Bioscience™ Supplier No. 7825/10

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1586.54 DKK valid until 2026-05-31
BEDSTE tilbudspris! Brug kampagnekoden "28002" for at få din tilbudspris.
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Description

Potent and selective DNA-PK inhibitor

AZD 7648 is a potent (IC50 = 0.6 nM in an enzyme assay) and selective DNA-PK inhibitor. It is selective for DNA-PK over a range of kinases including PI3Kα, PI3Kδ, PI3Kγ, ATM, ATR and mTOR. In combination with radiotherapy, it leads to tumor regression in fully immuno-competent mice models. It also enhances the activity of PARP inhibitor Olaparib (Cat. No. 7579). AZD 7648 is orally bioavailable.
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Specifications

Kemisk navn eller materiale 7,9-Dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-8H-purin-8-one
CAS 2230820-11-6
Mængde 10 mg
Mål DNA-dependent Protein Kinase Inhibitors
Molekylær formel C18H20N8O2
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