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Tocris Bioscience™ AZD 5248

Artikelnummer. 18735766
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Mængde:
1 mg
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Artikelnummer. 18735766

Brand: Tocris Bioscience™ 7130/1

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Description

Potent cathepsin C inhibitor

AZD 5248 is a potent cathepsin C (also known as dipeptidyl peptidase 1, or DPP1) inhibitor (IC50 values are 44 and 67 nM for human and rat, respectively). In vivo, AZD 5248 inhibition of cathepsin C correlates to the reduction of NSP (neutrophil serine protease) activity measured in rat bone marrow and blood. In rats, quantitative whole-body autoradiography studies demonstrate aortic binding of AZ 5248. This compound is orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Kemisk navn eller materiale 4-Amino-N-[(1S)-1-cyano-2-(4'-cyano[1,1'-biphenyl]-4-yl)ethyl]tetrahydro-2H-pyran-4-carboxamide
CAS 1254318-44-9
Mængde 1 mg
Mål Synthetic Cathepsin Inhibitors
Molekylær formel C22H22N4O2
Renhed 0.98
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