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Tocris Bioscience™ AUNP 12
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Artikelnummer. 18004282
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Mængde:
1 mg
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18004282 1 mg
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Artikelnummer. 18004282 Leverandør Tocris Bioscience™ Leverandørnr. 7831/1

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Beskrivelse

Peptide inhibitor of the PD-1 signaling pathway

AUNP 12 is an immune checkpoint modulator targeting the programmed cell death 1 (PD-1) signaling pathway. It inhibits the interaction between PD-1 and its ligands, PD-L1 and PD-L2. In the mouse splenocyte assay system, AUNP 12 rescues proliferation (EC50 values are 17 and 16 nM for PD-L1 and PD-L2, respectively) and enhances T-cell activity by restoring IFNγ release inhibited by PD-L1 and PD-L2 (EC50 values are 49 nM and 51 nM respectively). In a mouse Renca renal cell carcinoma model, AUNP 12 shows an additive antitumor effect when combined with Cyclophosphamide (Cat. No. 4091).
TRUSTED_SUSTAINABILITY

Tekniske data

Gen-id (Entrez) 5133
Renhed 95%
CAS 1353563-85-5
Indhold og opbevaring Store at -20°C
Gene Alias B7-DC, B7H1, B7-H1, Butyrophilin-like Protein, CD273, CD274, CD279, CD279 antigen, hPD-1, IFG, IFI, IFNG, IFNgamma, PD1, PD1hPD-l, PDCD1, PDCD1L1, PDCD1LG1, PDCD1LG2, PDL1, PDL2, programmed cell death 1, programmed cell death protein 1, Protein PD-1, SLEB2
Molekylvægt (g/mol) M.W. (Observed): 3261.56
Mængde 1 mg
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