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Tocris Bioscience™ ASP 7967

Artikelnummer. 31912119
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31912119 10 mg
31912114 50 mg
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Artikelnummer. 31912119 Leverandør Tocris Bioscience™ Leverandørnr. 8803/10

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Beskrivelse

Ligand for RNA aptamer AC17-4 activating gene expression in aptazime-based riboswitches

ASP 7967 is a ligand for RNA aptamer AC17-4 that activates gene expression in synthetic aptazime-based riboswitches at as low as 5 μM concentration, without relying on exogenous protein factors. ASP 7967 binds aptamer AC17-4 with high affinity in HEK293 cells (Kd = 12 nM; EC50 = 2.3 μM), activating gene expression (>10-fold) in HEK293 cells. ON/OFF ratio of riboswitches activated by ASP 7967 approaches 300, with a low basal expression level in cultured cells.

In vivo, ASP 7967 upregulates the serum hEPO concentration by 7.2-fold over the vehicle control (mice). Cell permeable and low-toxic, ASP 7967 is orally bioavailable.

TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale N2,N4-Bis(4-fluorophenyl)-N6-(2-pyrimidinylmethyl)-1,3,5-triazine-2,4,6-triamine hemifumarate
CAS 1246958-42-8
Mængde 10 mg
Mål DNA, RNA and Protein Synthesis Compounds
Molekylær formel C20H16F2N8.½C4H4O4
Renhed 98%
Produkttitel
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