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Ascomycin, 95%

Artikelnummer. 15488229
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25 mg
100 mg
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25mg
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Artikelnummer. 15488229 Leverandør Thermo Scientific Alfa Aesar Leverandørnr. J66751.MC
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Beskrivelse

Internal standard for LC-MS/MS testing of the immunosuppressants tacrolimus, sirolimus, and everolimus. | CAS: 104987-12-4 | C43H69NO12 | 792.02 g/mol

Ascomycin is a potent immunosuppressive agent that could be used as a potential therapeutic agent for autoimmune diseases. Ascomycin is an inhibitor of PP2. It is an internal standard for LC-MS/MS testing of the immunosuppressants tacrolimus, sirolimus, and everolimus. This Certified Spiking Solution™ is suitable for critical quantitative applications in clinical and diagnostic testing such as therapeutic drug monitoring assays to ensure patients remain within the narrow therapeutic range of these immunosuppressants.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Ascomycin is a potent immunosuppressive agent that could be used as a potential therapeutic agent for autoimmune diseases. Ascomycin is an inhibitor of PP2. It is an internal standard for LC-MS/MS testing of the immunosuppressants tacrolimus, sirolimus, and everolimus. This Certified Spiking Solution® is suitable for critical quantitative applications in clinical and diagnostic testing such as therapeutic drug monitoring assays to ensure patients remain within the narrow therapeutic range of these immunosuppressants.

Solubility
Soluble in DMSO at 65mg/ml; soluble in ethanol at 50mg/m; with warming. Very poorly soluble in water

Notes
Research Use only: Not intended for animal or human diagnostic or therapeutic use.
TRUSTED_SUSTAINABILITY

Kemiske identifikatorer

CAS 104987-12-4
Molekylær formel C43H69NO12
Molekylvægt (g/mol) 792.02
MDL nummer MFCD06198665
InChI nøgle ZDQSOHOQTUFQEM-NURRSENYSA-N
Synonym ascomycin, immunomycin, unii-auf4u5nsjk, ascomycin fk520, auf4u5nsjk, chembl8597, 15,19-epoxy-3h-pyrido 2,1-c 1,4 oxaazacyclotricosine-1,7,20,21 4h,23h-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-2-4-hydroxy-3-methoxycyclohexyl-1-methylethenyl-14,16-dimethoxy-4,10,12,18-tetram, ascomycin from streptomyces hygroscopicus var. ascomyceticus, 15,19-epoxy-3h-pyrido 2,1-c 1,4 oxaazacyclotricosine-1,7,20,21 4h,23h-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-8-ethyl-3-2-4-hydroxy-3-methoxycyclohexyl-1-methylethenyl-14,16-dimethoxy-4,10,12,18-tetramethyl-, 3s-3r* e 1s*,3s*,4s* ,4s*,19s*,26ar*, ascomycin fk 520, fr 900520, imm
PubChem CID 5282071
ChEBI CHEBI:29582
SMIL CCC1C=C(CC(CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC1=O)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC)C)C

Tekniske data

Kemisk navn eller materiale Ascomycin
Smeltepunkt 156°C to 160°C
Kogepunkt 868°C
Flammepunkt >110°C (230°F)
Emballage Plastic bottle
Mængde 100 mg
Opløselighedsinformation Soluble in DMSO at 65mg/ml; soluble in ethanol at 50mg/m; with warming. Very poorly soluble in water
Formel vægt 790
Procent renhed 95%
Fysisk form Powder

RUO – Research Use Only

Produkttitel
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