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Tocris Bioscience™ AS 1842856
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Artikelnummer. 18715816
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Mængde:
10 mg
50 mg
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Artikelnummer. Mængde
18715816 10 mg
18756916 50 mg
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Artikelnummer. 18715816 Leverandør Tocris Bioscience™ Leverandørnr. 4265/10

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Beskrivelse

Potent and selective Foxo1 inhibitor; orally bioavailable

AS 1842856 is a potent and selective Foxo1 inhibitor (IC50 values are 33 nM at Foxo1 and >1 μM at Foxo3a and Foxo4); decreases Foxo-mediated promoter activity by 70%, 20% and 3% at Foxo1, Foxo4 and Foxo3, respectively. Regulates gluconeogenesis both in vitro and in vivo. Attenuates fasting plasma glucose level in diabetic db/db mice. Also suppresses autophagy, adipocyte differentiation and soluble guanylyl cyclase expression. Also inhibits STAT3 signaling in NSCLC. Orally bioavailable.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
CAS 836620-48-5
Mængde 10 mg
Molekylær formel C18H22FN3O3
Renhed 98%
Produkttitel
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