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Invitrogen™ ARHGEF11 Recombinant Rabbit Monoclonal Antibody (1I7H7)
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Rabbit Recombinant Monoclonal Antibody

1310.00 DKK - 3250.00 DKK

Tekniske data

Antigen ARHGEF11
Klon 1I7H7
Koncentration 0.97 mg/mL
Indhold og opbevaring -20°C, Avoid Freeze/Thaw Cycles
Applikationer ELISA, Western Blot
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Produkter 2
Produktkode Brand Mængde Pris Antal & tilgængelighed  
Produktkode Brand Mængde Pris Antal & tilgængelighed  
30282774
Dokumentvisning
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Invitrogen™
MA557913 		20 μL
1310.00 DKK
20µL
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30283352
GREENER_CHOICE
Dokumentvisning
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Invitrogen™
MA557914 		100 μL
3250.00 DKK
100µL
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Beskrivelse

Beskrivelse

Immunogen sequence: QGVDQSPKPL IIGPEEDYDP GYFNNESDII FQDLEKLKSR PAHLGVFLRY IFSQADPSPL LFYLCAEVYQ QASPKDSRSL GKDIWNIFLE KNAPLRVKIP EMLQAEIDSR LRNSEDARGV LCEAQEAAMP EIQEQIHDYR TKRTLGLGSL YGENDLLDLD GDPLRERQVA EKQLAALGDI LSKYEEDRSA PMDFALNTYM SHAGIRLREA.

ARHGEF11 is a 1527 amino acid protein with tandem dbl homology and pleckstrin homology domains, PDZ domain, two proline rich sequences and a regulatory G protein-signaling (RGS) sequence. It acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase, but not for RAC1 or CDC42 and acts as GTPase-activating protein (GAP) for GNA12 and GNA13. It forms a complex with G proteins and stimulates neurite through retraction Rho-dependent signals. ARHGEF11 increases glutamate transport 4-fold. It interacts with EAAT4 and modulates its uptake activity and perisynaptic distribution at glutamatergic synapses. It is known to induce the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. It is ubiquitously expressed, in brain, lung, liver, kidney and skeletal muscle.
Tekniske data

Tekniske data

ARHGEF11
0.97 mg/mL
ELISA, Western Blot
Unconjugated
Rabbit
RUO
PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
Arhgef11; B930073M02; E130307F09; glutamate transporter EAAT4 associated protein 48; glutamate transporter EAAT4-associated protein 48; Gtrap48; KIAA0380; mKIAA0380; PDZ-RhoGEF; Prg; Rho guanine exchange factor (GEF) 11; Rho guanine nucleotide exchange factor (GEF) 11; rho guanine nucleotide exchange factor 11; RhoA-specific guanine nucleotide exchange factor; RhoGEF; RhoGEF glutamate transport modulator; RhoGEF glutamate transport modulator GTRAP48; RP11-356J7.2
ARHGEF11
Primary
Protein A
1I7H7
-20°C, Avoid Freeze/Thaw Cycles
Recombinant Monoclonal
Liquid
IgG
Mouse
ARHGEF11
213498
Recombinant fusion protein containing a sequence corresponding to amino acids 281-490 of human ARHGEF11 (NP_055599.1).
Antibody
Videoer
SDS
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