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Tocris Bioscience™ AP 20187
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Artikelnummer. 18788946
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5 mg
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18788946 5 mg
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Artikelnummer. 18788946 Leverandør Tocris Bioscience™ Leverandørnr. 6297/5

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Beskrivelse

Chemical inducer of protein dimerization; active in vivo

AP 20187 is a chemical inducer of dimerization (CID) for use in FKBP fusion protein systems. Induces apoptosis in cells expressing fusion proteins consisting of FKBPF36V and the intracellular domain of the Fas receptor, Fas-associated death domain (FADD) or a caspase. Selective for FKBPF36V-Fas fusion proteins over wild-type FKBP. Induces apoptosis of senescent cells expressing caspase-8-FKBP fusion proteins under the control of an Ink4a promoter. Active in vivo.
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Tekniske data

Kemisk navn eller materiale 2,2 '-[[2-[(Dimethylamino)methyl]-1,3-propanediyl]bis[imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene[(1 R)-3-(3,4-dimethoxyphenyl)propylidene]]] bis[1-[(2 S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate]
CAS 195514-80-8
Mængde 5 mg
Mål Protein Dimerizers
Molekylær formel C82H107N5O20
Renhed 0.98
Produkttitel
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