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Tocris Bioscience™ AP 1903
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Artikelnummer. 18727356
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Mængde:
5 mg
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18727356 5 mg
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Artikelnummer. 18727356 Leverandør Tocris Bioscience™ Leverandørnr. 6130/5

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Beskrivelse

Chemical inducer of protein dimerization; active in vivo

AP 1903 is a chemical protein dimerizer for use in FKBP fusion protein systems. Induces apoptosis in cells expressing a fusion protein consisting of FKBPF36V and intracellular domain of Fas receptor with high potency (EC50 = 0.1 nM). Exhibits >50-fold selectivity for FKBPF36V-Fas fusion protein over wild-type FKBP. Also induces apoptosis in cells expressing Cas9-FK506 fusion proteins, in inducible caspase 9 (iCas9) suicide gene system. Active in vivo.
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Tekniske data

Kemisk navn eller materiale 2,2 '-[1,2-Ethanediylbis[imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene[(1 R)-3-(3,4-dimethoxyphenyl)propylidene]]] bis[(2 S)-1-[(2 S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate]
CAS 195514-63-7
Mængde 5 mg
Mål Protein Dimerizers
Molekylær formel C78H98N4O20
Renhed 0.98
Produkttitel
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