Varicella zoster Virus Mouse anti-Virus, Clone: SG3, Invitrogen™

Description

MA1-90605 detects Varicella Zoster virus from human samples. MA1-90605 has been successfully used in immunofluorescence, immunoprecipitation, Western blot applications. The MA1-90605 immunogen is: Tissue / cell preparation (VZV Ellen Strain).

Varicella Zoster Virus (VZV), a member of the human herpes virus family, causes two distinct clinical manifestations: childhood chickenpox(Varicella) and shingles (zoster). Varicella is the outcome of the primary infection with VZV, whereas, zoster is the result of VZV reactivation from latently infected sensory ganglia which occurs precomitly in aging and immunosuppressed individuals. Glycoprotein E (gE), a 623 amino acid type I integral membrane protein, is expressed on plasma membranes and in the cytoplasm of VZV infected cells, where it is presumed to be present in the membranes of intracellular vesicles or organelles. VZV gE complexes with gI in the rough endoplasmic reticulum, and most gE exists in the form of gE to gI heterodimers in infected cells. VZV gE is also a predomit component of the virion envelope. The functions of gE, which is encoded by ORF68, are of particular interest because it has been demonstrated that ORF68 is essential for VZV replication. In contrast, the genes for gE proteins can be deleted from herpes simplex virus and pseudorabies virus, albeit with significant reductions in infectivity in cell culture and in animal models. Since the VZV genome does not encode a homologue of gD, VZV gE may have functions that are usually segregated between gD and gE, or the gE to gI complex, in other alphaherpesviruses.