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JAK1 Mouse, Unlabeled, Clone: 73, BD

Artikelnummer. 15835349
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150 μg
50 μg
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15835349 150 μg
15825349 50 μg
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Artikelnummer. 15835349 Leverandør BD Biosciences Leverandørnr. 610232

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Beskrivelse

Mouse Monoclonal Antibody

The JAK family of receptor-associated protein kinases is directly involved in interferon (IFN) response pathways. The JAK family contains at least three members: JAK1, JAK2, and Tyk2. Each protein is approximately 130kDa and contains a C-terminal tyrosine kinase domain, an adjacent kinase or kinase-related domain, and five other domains that are highly conserved among family members. In several human and murine cell lines, JAK1 is rapidly tyrosine phosphorylated in response to IFN-α and IFN-γ. JAK1 is required for the phosphorylation of the transcription factor Stat1 (p91), in response to IFNs-α or IFN-γ. JAK1 is also necessary for the efficient phophorylation of Stat2 (p113) in response to IFN-α and for the phosphorylation of Tyk2 or JAK2 in response to IFNs-α or IFN-γ, respectively.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

TRUSTED_SUSTAINABILITY

Tekniske data

Antigen JAK1
Applikationer Western Blot
Klassifikation Monoclonal
Klon 73
Koncentration 250μg/mL
Konjugeret Unconjugated
Formulering Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Værtsarter Mouse
Immunogen Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Oprensningsmetode Affinity Purified
Mængde 150 μg
Regulatorisk status RUO
Forskningsdisciplin Cell Biology
Primær eller sekundær Primary
Målarter Canine, Chicken, Frog, Human, Mouse, Rat
Indhold og opbevaring Store undiluted at -20°C.
Isotype IgG2b κ
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For Research Use Only.

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