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Epstein Barr Virus LMP2A Monoclonal Antibody (15F9), Invitrogen™
Rat Monoclonal Antibody
Brand: Invitrogen MA181921
Additional Details : Weight : 0.01000kg
Description
Heat-mediated antigen retrieval using a sodium citrate buffer (pH 6.0) is recommended for the staining of paraffin sections. Rat anti Epstein-Barr Virus LMP2A antibody, clone 15F9 recognizes latent membrane protein 2A (LMP2A) of Epstein-Barr virus (EBV).
Epstein-Barr virus (EBV) is a human herpes virus, which is associated with conditions such as Hodgkin's disease and Burkitt's Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.EBNA-1 is the only viral protein consistently expressed in all malignancies associated with EBV.Specifications
Epstein Barr Virus LMP2A | |
Monoclonal | |
1 mg/mL | |
PBS with 0.09% sodium azide; pH 7.4 | |
Rat | |
Protein G | |
RUO | |
Virus | |
Antibody | |
IgG1 |
Immunohistochemistry (Paraffin), Western Blot | |
15F9 | |
Unconjugated | |
EBV | |
Bacterial TrpE-LMP2A fusion protein. | |
250 μg | |
Primary | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |